Myoepithelial cells (MECs) are a unique subset of cells of ectodermal origin, possessing characteristics similar to smooth muscle cells, including abundant actin-myosin filaments and contractile capabilities. Beyond their conventional role in acini contraction, there is a growing interest in uncovering additional functions of MECs, particularly in the morphogenesis, regeneration, and pathology of lacrimal and salivary glands. Our research presents compelling evidence that MECs serve as key contributors to these glands dysfunction. As a result, various properties of MECs are impacted in pathological contexts, presenting potential targets for restoring optimal tear and saliva production.

​